CASNumber200336-86-3
LinearFormulaC₂₈H₂₇NO₆
MolecularWeight473.52 g/mol
Properties:
| RelatedCategories | AminoAcids&Derivatives,AsparticAcid,ChemicalBIOLOGy,ChemicalSynthesis,PeptideChemistry |
Description:
Backgroundinformation
Quasi-orthogonally-protectedAspderivative.
The2-PhiPrgroupcanberemovedselectivelyinthepresenceoftBu-basedprotectinggroupsbytreatmentwith1%TFAinDCM[1],makingthisderivativeanextremelyusefultoolforthepreparationofcyclicpeptidesbyFmocSPPS[2]orforlibrarysynthesis.Fortheon-resinsynthesisofside-chaintoside-chainlactambridgedpeptides,thecombinationofLys(Mtt)andAsp(O-2-PhiPr)isparticularlyadvantageoussincebothside-chainscanbesimultaneouslyunmaskedinasinglestep.
Thisderivativehasalsobeenusedinsolutiontopreparebicyclichelixinitiatingpeptides[3].
Theproductnumberforthisproductwaspreviously04-12-1200
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Toobtainacertificateofanalysis(CoA)ofalotthatbeginswiththeletter"A",pleaseselecttheoptionintherighthandmenu"RequestaCOAforLot#sstartingwithA".
