Popular Documents: Bulletin(PDF) | SpecificationSheet(PDF)
Properties:
| RelatedCategories | AminoAcidMetabolismAssayKits,BloodandUrineChemistryAssayKits,CellBIOLOGy,EnzymaticActivityAssayKits,EnzymaticKitsfortheQuantitationofNutrientsandMetabolites, |
| usage | sufficientfor200 colorimetric tests |
| GeneInformation | human...ARG1(383),ARG2(384) mouse...ARG1(11846),ARG2(11847) rat...ARG2(29215),Arg1(29221) |
Description:
FeaturesandBenefits
CompatIBLewithhigh-throughputhandlingsystems.
OtherNotes
Thiskitisshippedatroomtemperature.StoretheArginaseBufferandUreastandardat−20°C.Allothercomponentsarestoredat2-8°C.
Generaldescription
Arginaseisamanganese-containingenzymethatcatalyzestheconversionofargininetoureaandornithine.Twoisoformsofarginasearepresentinmostmammalswhichdifferintheirtissuedistributionandsubcellularlocalization.ArginaseIisacytoplasmicproteinpredominantlyexpressedintheliverwhereitcatalyzesthefifthandfinalstepoftheUreaCycle.ArginaseIIisamitochondrialproteinwithbroadertissuedistributionwhosefunctionmayincludenitricoxideandpolyaminemetabolism.DecreasedactivityorexpressionofArginaseIresultsintheautosomalrecessivedisorderhyperarginemia.IncreasedserumArginaseactivityisimplicatedinhepaticinjuryandincertainpathologicalconditionssuchascancer.Arginasealsoparticipatesinmultipleinflammatoryreactionsintheimmunesystem.
Inthisassay,arginasecatalyzestheconversionofargininetoureaandornithine.Theureaproducedspecificallyreactswiththesubstratetogenerateacoloredproduct,proportionaltothearginaseactivitypresent.
SuitABIlity
Suitableforthedetectionofarginaseactivityinenzymepreparations,serum,plasma,tissueculture,andsimilarsamples.Suitableforstudyingtheeffectsofdrugsonarginaseactivity.
Safety:
GHS05,GHS07,GHS08,GHS09
