CASNumber148515-85-9
LinearFormulaC₄₁H₃₅NO₈
MolecularWeight669.72 g/mol
Properties:
| RelatedCategories | Alanine,AminoAcids&Derivatives,ChemicalBIOLOGy,ChemicalSynthesis,PeptideChemistry |
Description:
Backgroundinformation
Hmbprotectionofamidebondshasbeenshowntoinhibitaggregationof"difficult"peptides,therebyleADIngtoproductsofincreasedpurity[1-6].RetentionofHmbgroupsonthecleavedpeptidecangreatlyimprovethesolubilityofprotectedpeptidefragments[7-8]andotherwiseintractablesequences[9-11].FurThermore,usingaHmb-protectedderivativeforincorporationoftheresiduelinkedtothecarboxylgroupofAsporAsnresidueshasbeenfoundtosuppressformationofaspartimideandpiperididerelatedby-products[12-14].ForacomparisonoftheefficiencyofHmbandpseudoprolinesinpreventingaggregation,see[15].
Theproductnumberforthisproductwaspreviously04-12-1127.
Toobtainacertificateofanalysis(CoA)ofalotthatbeginswiththeletter"A",pleaseselecttheoptionintherighthandmenu"RequestaCOAforLot#sstartingwithA".
