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CAS Number 71395-14-7
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Empirical Formula (Hill Notation) C11H16N2O · HCl
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Molecular Weight 228.72
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MDL number MFCD00941502
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PubChem Substance ID 329751330
Properties:
| Related Categories | Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards S - T |
Description:
Biochem/physiol Actions
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
USP issued SDS can be found here.
Features and Benefits
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 μM in blockade of inactivated-state sodium channels; IC50 = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 μM in blockade of Na+ currents at HP -70 mV; IC50 = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 μM for use-dependent block at 10 Hz.
Safety:
GHS07
