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Sigma-Aldrich/SupelMIP® SPE - Full Beta-receptor (beta-blockers and beta-agonists)/53224-U/
Properties:
| Related Categories | Analytical/Chromatography, Sample Preparation & Purification, Solid Phase Extraction (SPE), SupelMIP Molecular Imprinted Polymers, SupelMIP SPE - Full Beta-receptor (beta-blockers and beta-agonists) |
Description:
Application
Developed for the selective extraction of both beta-agonists and beta-blockers from human urine and waste water.
The method is highly reproducible and offers extraction recoveries of 50-90% from 1 mL urine with minimal ion-suppression when analyzing via LC-MS/MS conditions.
Features and Benefits
• Highly selective SPE for trace analysis in complex matrices
• Achieve lower detection limits
• Significant time and cost savings
• Improved MS-compatibility
General description
SupelMIP SPE phases were developed by MIP Technologies AB, which is one of the leading authorities and commercial pioneers of molecular imprinted polymers for process scale separations, analytical chromatography, and sample preparation.
The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.
By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.
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Legal Information
SupelMIP is a registered trademark of Sigma-Aldrich Co. LLC
