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CAS Number 84625-61-6
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Empirical Formula (Hill Notation) C35H38Cl2N8O4
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Molecular Weight 705.63
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MDL number MFCD00870168
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PubChem Substance ID 329823629
Properties:
| Related Categories | Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI Key |
VHVPQPYKVGDNFY-UHFFFAOYSA |
| packaging | pkg of 200 mg |
| pharmacopeia traceability | traceable to PhEur I7000000 |
| traceable to USP 1354251 |
Description:
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Other Notes
This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).
Biochem/physiol Actions
Itraconazole inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAB3721 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
Safety:
GHS07
