CASNumber4759-48-2
EmpiricalFormula(HillNotation)C20H28O2
MolecularWeight300.44
MDLnumberMFCD00079542
PubChemSubstanceID329750208
Properties:
| RelatedCategories | AnalyticalStandards,Analytical/Chromatography,Pharmacopeia&MetrologicalInstitutesStandards,USPStandards,USPStandardsI-K |
Description:
Biochem/physiolActions
13-cis-Retinoicacid(RA)hasanti-inflammatoryandanti-tumoraction.TheactionofRAismediatedthroughRAR-βandRAR-αreceptors.RAattenuatesiNOSexpressionandactivityincytokine-stimulatedmurinemesangialcells.ItinducesmitochondrialmembranepermeABIlitytransition,observedasswellingandasadecreaseinmembranepotential,andstimulatesthereleaseofcytochromecimplicatingmechanismsthroughtheapoptosispathway.TheseactivitiesarereversedbyEGTAandcyclosporinA.RAalsoincreasesMMP-1proteinexpressionpartiallyviaincreasedtranscription.
Generaldescription
ThisproductisprovidedasdeliveredandspecifiedbytheissuingPharmacopoeia.Allinformationprovidedinsupportofthisproduct,includingSDSandanyproductinformationleafletshavebeendevelopedandissuedundertheAuthorityoftheissuingPharmacopoeia.ForfurtherinformationandsupportpleasegotothewebsiteoftheissuingPharmacopoeia.
OtherNotes
Salesrestrictionsmayapply.
USPissuedSDScanbefoundhere.
Safety:
GHS07,GHS08
