• CASNumber4759-48-2

• EmpiricalFormula(HillNotation)C₂₀H₂₈O₂

• MolecularWeight300.44

•  MDLnumberMFCD00079542

•  PubChemSubstanceID329815327

Properties:

Description:

Biochem/physiolActions

13-cis-Retinoicacid(RA)hasanti-inflammatoryandanti-tumoraction.TheactionofRAismediatedthroughRAR-βandRAR-αreceptors.RAattenuatesiNOSexpressionandactivityincytokine-stimulatedmurinemesangialcells.ItinducesmitochondrialmembranepermeABIlitytransition,observedasswellingandasadecreaseinmembranepotential,andstimulatesthereleaseofcytochromecimplicatingmechanismsthroughtheapoptosispathway.TheseactivitiesarereversedbyEGTAandcyclosporinA.RAalsoincreasesMMP-1proteinexpressionpartiallyviaincreasedtranscription.

Caution

PleasefindSDSprovidedbyEDQMhere..

Generaldescription

ThisproductisprovidedasdeliveredandspecifiedbytheissuingPharmacopoeia.Allinformationprovidedinsupportofthisproduct,includingSDSandanyproductinformationleafletshavebeendevelopedandissuedundertheAuthorityoftheIssuingPharmacopoeia.ForfurtherinformationandsupportpleasegotothewebsiteoftheissuingPharmacopoeia.

OtherNotes

Salesrestrictionsmayapply.

Packaging

Unitquantity:50mg.Subjecttochange.TheproductisdeliveredassuppliedbytheissuingPharmacopoeia.Forthecurrentunitquantity,pleasevisittheEDQMreferencesubtancecatalogue.

Safety:

Symbol 

  GHS07,GHS08